7 NEW KINASE INHIBITORS RELEASED |
| |
|
 |
|
| GNE 477 |
| SYN-1148 |1032754-81-6 |
| GNE 477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC50 value of 4nmol/L and 21nmo... |
|
|
|
|
| AS-602801 |
| SYN-1147 |848344-36-5 |
| AS-602801 is a novel, orally active JNK-1 inhibitor entering into Phase II trials for prevention of ... |
|
|
|
|
| CH5132799 |
| SYN-1146 |1007207-67-1 |
| CH5132799 selectively inhibits class I PI3K and PI3Kα mutants in vitro with an IC50 value of 14nmol... |
|
|
|
|
| NIBR-17 |
| SYN-1145 |944396-88-7 |
| NIBR-17 is a pan class I PI3K inhibitor with IC50 values 0.001, 0.092, 0.009 and 0.020uM respectivel... |
|
|
|
|
| AMG-458 |
| SYN-1144 |913376-83-7 |
| AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against V... |
|
|
|
|
| AMG-1 |
| SYN-1143 |913376-84-8 |
| AMG-1 is a potent inhibitor of human c-Met and RON with IC50 of 4 and 9 nmol/L respectively.... |
|
|
|
|
|
