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11 NEW KINASE INHIBITORS RELEASED |
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| AMG-51 |
| SYN-1111 |890019-63-3 |
| It shows the enzyme selectivity of c-Met with Ki=4.9nM, KDR with Ki=139nM, Ron with Ki=28nM, IGFR wi... |
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| Pelitinib |
| SYN-1141 |257933-82-7 |
| Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineop... |
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| Neratinib |
| SYN-1140 |698387-09-6 |
| Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 n... |
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| Crizotinib |
| SYN-1139 |877399-52-5 |
| PF-2341066 potently inhibited cell proliferation, which was associated with G1-S–phase cell cycle ... |
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| Cabozantinib |
| SYN-1138 |849217-68-1 |
| Cabozantinib is very potent, with IC50 under 10 nM for VEGFR2, MET, Kit and FLT3-ITD mechanistic ass... |
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| XL765 |
| SYN-1137 |1123889-87-1 |
| XL765 is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110α, β, γ... |
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| Latest News |
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SynKinase Newsletter Jan 2012
A kinase interaction map profiling the activity of 178 commercially available kinase inhibitors agai... |
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New! SUBSCRIPTION SERVICE
Agree to a minimum monthly purchase value and receive substantial discounts on all kinase inhibitors... |
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